Can I take Melatonin with Trazodone for Sleep

by Sehrish Vulvox ABC

If you have trouble sleeping, you may have heard about taking melatonin or trazodone to help you fall asleep. Both of these substances are commonly used to promote sleep, but can they be taken together? In this article, we will explore whether it is safe to take melatonin with trazodone and what potential interactions may exist.

What is Melatonin?

Melatonin is a hormone that is naturally produced by the body’s pineal gland. It is commonly used as a sleep aid, as it regulates the body’s circadian rhythm and helps to promote sleepiness. Melatonin supplements are available over the counter and are commonly used to help with insomnia, jet lag, and other sleep disturbances.

What is Trazodone?

Trazodone is a medication that is commonly used to treat depression and anxiety. It is also used off-label as a sleep aid, as it can help to promote drowsiness and improve sleep quality. Trazodone is a sedative, and its effects on the body can last for several hours after it is taken.

How do Melatonin and Trazodone Work?

Melatonin works by regulating the body’s sleep-wake cycle. It is produced in response to darkness and is suppressed by light. When melatonin levels rise in the body, it signals to the brain that it is time to sleep. Trazodone works by increasing the levels of certain neurotransmitters in the brain, including serotonin and norepinephrine. This helps to promote feelings of relaxation and sleepiness.

Can Melatonin and Trazodone be Taken Together?

Melatonin and trazodone can be taken together, but it is important to speak with a healthcare provider before doing so. While there are no known interactions between melatonin and trazodone, combining these substances may increase the sedative effects of trazodone. This can lead to drowsiness, dizziness, and difficulty concentrating.

Potential Interactions of Melatonin and Trazodone

While there are no known interactions between melatonin and trazodone, it is important to be aware of the potential risks associated with taking these substances together. Combining these substances may increase the risk of side effects such as dizziness, drowsiness, and confusion. It may also increase the risk of falls or accidents, especially in older adults.

Recommended Dosages of Melatonin and Trazodone

The recommended dosage of melatonin varies depending on the individual and the reason for use. Generally, a dose of 1-10mg is taken 30-60 minutes before bedtime. Trazodone is typically prescribed at doses of 50-100mg per day for depression and anxiety, and at higher doses (up to 300mg) for insomnia.

What Should You Tell Your Doctor Before Taking Melatonin and Trazodone?

Before taking melatonin and trazodone together, it is important to discuss with your doctor whether it is safe for you to take these medications together. Here are some important things to consider and discuss with your doctor:

  • Your Medical History: Your doctor will want to know about your medical history, including any pre-existing conditions, allergies, or past surgeries. Be sure to inform your doctor if you have ever had any adverse reactions to either melatonin or trazodone.
  • Other Medications: Inform your doctor about any other medications, vitamins, or supplements you are currently taking. Certain medications may interact with melatonin or trazodone and cause unwanted side effects or reduce the effectiveness of the medication.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, you should discuss the risks and benefits of taking melatonin and trazodone with your doctor. These medications may not be safe for use during pregnancy or while breastfeeding.
  • Mental Health Conditions: Inform your doctor if you have a history of depression, anxiety, or other mental health conditions. Melatonin and trazodone may worsen these conditions or interact with other medications used to treat them.
  • Sleep Apnea: If you have sleep apnea or any other sleep disorder, discuss this with your doctor before taking melatonin and trazodone. These medications may interfere with your breathing during sleep and worsen your condition.

By discussing these factors with your doctor, you can ensure that melatonin and trazodone are safe for you to take together and that you are taking the correct dosage for your needs. Always follow your doctor’s instructions and do not exceed the recommended dosage without their approval.


In conclusion, taking melatonin and trazodone together for sleep should only be done under the guidance and supervision of a healthcare professional. Before taking any medication, it is important to discuss your medical history, other medications, and any pre-existing conditions with your doctor. Additionally, there are many other sleep solutions available, including lifestyle changes, natural remedies, and professional help, that may be effective for improving sleep quality. By being proactive and seeking help when needed, you can improve your sleep and overall well-being. Remember to always follow your doctor’s instructions and prioritize your health and safety when considering any sleep solutions.

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