How Does Semaglutide Work for Weight Loss

by vulvoxagency

Our bodies produce the modified GLP1 molecule known as semaglutide. It is a protein that is produced in the intestine and lowers blood sugar and hunger. The medicine can now stay in our bodies for weeks as opposed to just a few minutes thanks to a minor molecular alteration. Semaglutide is an enhanced dosage of the same medication, which was first prescribed for diabetes and now marketed as Ozempic, to help people lose weight.

Semaglutide and Weight Loss Research

In the aforementioned trial, obese subjects (BMI > 30) received 2.4 mg of semaglutide per week for 68 weeks. 15% of the body weight was lost by the therapy group. The placebo group experienced a 2.4% weight loss. When used in conjunction with a medical weight loss regimen, outcomes could be even better.

Semaglutide: How Does It Operate?

The following are some of the ways semaglutide works: This results in reduced meal portions and a fullness and satisfaction sensation.

  • Reduces bowel motion.
  • Lowers blood sugar levels, in part by decreasing the liver’s ability to produce sugar.
  • Encourages the pancreas to secrete insulin.

Diabetes medications for weight loss

At a dose of 1 mg per day, semaglutide is now FDA-approved for the treatment of type 2 diabetes. Compared to other diabetes medications, it produces some of the finest weight loss results. Sulfonylureas and insulin are two diabetic treatments that might increase body weight.

Semaglutide helps obese individuals lose extra body fat

An industry-sponsored study presented online at ENDO 2021, the Endocrine Society’s annual meeting, found that weekly therapy with the glucagon-like peptide 1 (GLP1) receptor agonist semaglutide reduces excess body fat and increases lean body mass in persons who are obese or overweight.

According to lead author John Wilding, D.M., F.R.C.P. of the University of Liverpool, “our findings suggest that semaglutide, through body weight loss and improvement of body composition, has the potential to reduce the risk of heart disease, diabetes, and stroke in people who are overweight or obese.

The leading causes of death and disability, such as heart attacks, strokes, high blood pressure, cancer, fatty liver disease, and diabetes, are all influenced by excess abdominal fat, particularly visceral fat, which is fat in and around the abdominal organs. 1,961 persons with a body mass index (BMI) of at least 27 and at least one weight-related health condition.

Dietitians and fitness experts are dubious about potential long-term hazards

Some people are sceptical of semaglutide as a weight loss treatment despite its purported advantages. Jillian Michaels, a celebrity fitness trainer, voiced worry that individuals seek the medicine.

Additionally, dietitians are concerned that since the effects of the hormone-shifting have not been studied over an extended period of time, they may have unintended long-term repercussions.

What Advantages Does Semaglutide Offer?

The advantages of semaglutide are numerous and include:

  • . Weight loss: It has been demonstrated that semaglutide can aid in weight loss of up to 10% of the body.
  • Semaglutide suppresses your appetite, which enables you to eat fewer calories and shed pounds.
  • Lessened Risk of Weight Gain: Semaglutide reduces appetite, making it less probable that you will put on the weight you’ve lost back on.
  • Better Blood Sugar Control: It has been demonstrated that semaglutide helps diabetics with better blood sugar management.
  • Semaglutide has been demonstrated to reduce blood pressure in those with hypertension.

What Adverse Reactions Can Semaglutide Cause?

Semaglutide’s most frequent negative effects include:

  • Headache
  • Nausea
  •  Diarrhea
  • Constipation
  • Dizziness
  • Fatigue

Most of the time, these side effects are minor and disappear on their own. Call your doctor right away and stop taking semaglutide if you encounter any serious adverse effects.

How Should I Consume Semaglutide?

Once a week, semaglutide is injected beneath the skin. The appropriate dose will be recommended by your doctor for you. You can receive the injections at home or in your doctor’s clinic. If you are administering semaglutide at home, be sure to carefully follow all directions.

 Semaglutide helps people lose weight by raising the amount of insulin that their pancreas produces and decreasing the amount of glucagon that their liver produces. Weight loss results from the combination of decreased hunger and greater energy.

How quickly does semaglutide start working to help you lose weight?

Semaglutide works swiftly even though it doesn’t cause weight loss right away. According to a research that appeared in The New England Journal of Medicine, semaglutide users lost more than 2% of their body weight in just four weeks.

How can you tell if semaglutide is effective?

Throughout the first week of using Ozempic (semaglutide) at your usual maintenance dose, your blood sugar levels should begin to significantly decrease. Nevertheless, because this is a long-acting medicine that is only injected once per week, the full effects may not be felt for 8 weeks or longer.

What diet is recommended when taking semaglutide?

Avoid fried, quick, fatty, and sugar-rich foods. Take a sip of water or unsweetened tea (clear drinks) Eat more frequently but more sparingly (good advice for any diet) Have bland and light foods, you’ll still feel full and don’t worry about it.


While semaglutide doesn’t provide immediate weight loss, it works quickly. A study published in The New England Journal of Medicine showed that after just four weeks of taking semaglutide, patients experienced more than a 2% reduction in body weight.

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