Introduction
Conclusions: Dietary alpha-lipoic acid supplementation in SHRs lowered the systolic blood pressure, cytosolic [Ca2+]i, blood glucose and insulin levels, and tissue aldehyde conjugates, and attenuated adverse renal vascular changes.
Does alpha-lipoic acid help to lose weight?
They found that the higher dose of ALA resulted in significant weight loss and BMI reduction throughout the study compared to placebo. The lower dose of ALA led to significant weight loss in the first weeks of this study, however this effect was not sustainable through the entire duration of the study.
What does alpha-lipoic acid do in the body?
Alpha-lipoic acid is an antioxidant made by the body. It is found in every cell, where it helps turn glucose into energy. Antioxidants attack “free radicals,” waste products created when the body turns food into energy.
How long does it take for alpha-lipoic acid to work?
A review of studies from the Netherlands showed that a daily 600 milligrams intravenous dose of ALA given over three weeks reduced neuropathic pain. 6 Another review found that daily intravenous doses of 300 milligrams to 600 milligrams for two to four weeks were safe and improved neuropathy symptoms.
What are the negative side effects of alpha-lipoic acid?
The most common side effects are headache, heartburn, nausea, and vomiting. When applied to the skin: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people.
Who should not take alpha-lipoic acid?
However, due to the adverse effects of ALA on animals and due to ALA’s physiological effects, one should consult with a doctor before taking it if they have the following conditions: Liver disease. Consumption of large amounts of alcohol. Diabetic (ALA is known to lower blood’s sugar)
Why do bodybuilders take alpha-lipoic acid?
ALA assists to prevent muscle damage caused by free radicals and speeds up muscle recovery. The multiple health benefits of ALA have made it a popular supplement among endurance and resistance athletes.
How long does it take to lose weight with alpha-lipoic acid?
In both the 1200 and 1800 mg/d alpha-lipoic acid groups, average weight decreased significantly from baseline, starting as early as 4 weeks (Figure 2). At 20 weeks, the mean body weight reduction was significantly greater in the 1800 mg/d alpha-lipoic acid group than in the placebo group.
What happens if you take too much alpha-lipoic acid?
Although ALA intoxication is very rare, it is sometimes seen after accidental or suicidal acute ingestion. Neurologic effects, metabolic acidosis, and t wave inversions in the EKG are observed when this acute poisoning occurs. Supportive treatment should be the main therapy.
Does alpha-lipoic acid cleanse the liver?
ALA helps with the treatment of liver damage, diabetes, cancer, and other diseases. Alpha Lipoic Acid can be used as an oral supplement or taken intravenously. It is believed that Alpha Lipoic Acid administered intravenously will assist in the detox of the liver and its regeneration.
Conclusion
Alpha-lipoic supplements are best taken on an empty stomach, as certain foods can lower the acid’s bioavailability (40). Though there is no set dosage, most evidence suggests that 300–600 mg is sufficient and safe.
